Research Articles
The Eukaryotic Cytoskeleton: Structure, Dynamics, and Emerging Therapeutic Targets
This article provides a comprehensive analysis of the eukaryotic cytoskeleton, exploring its fundamental structure and dynamic functions essential for cell integrity, division, and motility.
Viscoelastic Properties of Actin Filament Dendritic Networks: From Molecular Mechanisms to Biomedical Applications
This comprehensive review explores the viscoelastic properties of actin filament dendritic networks, integrating foundational biophysics with cutting-edge methodological approaches. We examine how dendritic nucleation architecture, cross-linker specificity, and geometrical constraints determine mechanical behavior across scales—from single filaments to complex networks. The article details experimental techniques like macrorheology and FRAP alongside computational models including finite-element analysis and Cytosim simulations. We address optimization challenges in network design, compare mechanical performance across network types, and validate models against experimental data. Finally, we discuss emerging biomedical applications in drug development, neurological disorders, and cytoskeleton-targeted therapies, providing researchers and drug development professionals with a multidisciplinary framework for understanding and manipulating these essential biological structures.
Nuclear Actin in Gene Regulation: From Transcriptional Mechanisms to Therapeutic Potential
This article synthesizes current knowledge on nuclear actin's multifaceted role in gene transcription, chromatin remodeling, and cellular reprogramming. Targeting researchers and drug development professionals, it explores foundational mechanisms of nuclear actin in RNA polymerase function, methodological advances for studying nuclear actin dynamics, troubleshooting for technical challenges, and validation through disease-relevant models. The review highlights nuclear actin as a central regulator of inducible transcription and discusses its emerging implications for understanding cancer biology and developing novel therapeutic strategies.
The Brain's Social Network: How Microscopic Cellular Handshakes Shape Our Minds
Explore Judith S. Cruz Ortega's groundbreaking research on latrophilins and their role in brain development and ADHD connections.
Cellular Highways: How Geometry and Teamwork Power Your Cells
Explore how cytoskeletal geometry and motor protein arrangement affect force generation and transport in cells through interactive visualizations and data.
The Invisible Touch: How Physical Forces Shape Our Genetic Destiny
Discover how mechanical forces influence gene expression through chromatin interactions and epigenetic modifications.
The Hidden Architect: How a Tiny Protein Could Revolutionize Stroke Recovery
Discover how Microfibrillar-associated protein 5 (MFAP5) could transform stroke treatment and brain recovery research.
The Cellular Postmaster: How DENND5B Directs Your Fat Absorption
Discover how DENND5B regulates triglyceride-rich lipoprotein secretion and its implications for obesity, cardiovascular health, and metabolic disorders.
Cracking the Heart's Code: How Gene Networks are Revolutionizing the Fight against Cardiovascular Disease
Discover how transcriptomics and multi-scale network analysis are transforming cardiovascular disease research and treatment through gene network mapping.
The Secret Highways of Virus Spread: How Ebola and Marburg Viruses Hijack Our Cells
Discover how Ebola and Marburg viruses use direct intercellular transport through tunneling nanotubes to spread while evading immune detection.