Research Articles
A Step-by-Step Protocol for Microtubule Tactoids Self-Assembly: From Reconstitution to Analysis
This article provides a comprehensive guide for researchers and scientists on the self-assembly of microtubule tactoids, which are spindle-shaped, liquid crystal-like structures that serve as minimalistic in vitro models for...
High-Throughput Actin Filament Quantification: Advanced Algorithms for Biomedical Research and Drug Discovery
The quantification of actin filaments provides critical insights into fundamental cellular processes and disease mechanisms.
In Vitro Reconstitution of Actin-Microtubule Composites: A Guide to Protocols, Dynamics, and Applications
This article provides a comprehensive resource for researchers and drug development professionals on the in vitro reconstitution of composite cytoskeletal networks.
Encapsulating Actin Cytoskeletons in Giant Unilamellar Vesicles: A Guide for Synthetic Cell Research
This article provides a comprehensive resource for researchers and professionals on the encapsulation of actin networks in Giant Unilamellar Vesicles (GUVs), a cornerstone of bottom-up synthetic biology.
The Perinuclear Actin Cap: A Central Hub in Nuclear Mechanotransduction and Cellular Sensing
This article synthesizes current knowledge on the perinuclear actin cap, a specialized cytoskeletal structure that connects the extracellular environment to the nucleus.
Cytoskeletal Defects in Neurodegeneration: Mechanisms, Therapeutic Targeting, and Future Directions
This article synthesizes current knowledge on cytoskeletal dysfunction as a central mechanism in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease.
Actin-Microtubule Crosstalk: Molecular Mechanisms and Biomedical Applications in Cell Biology
This comprehensive review synthesizes current understanding of the intricate crosstalk between actin filaments and microtubules, two dynamically coordinated cytoskeletal systems.
Cellular Mechanotransduction: Decoding Cytoskeletal Signaling Pathways in Health and Disease
This article provides a comprehensive analysis of the molecular mechanisms by which cells convert mechanical stimuli into biochemical signals through the cytoskeleton.
Cytoskeletal Dynamics in Health and Disease: From Molecular Mechanisms to Therapeutic Targeting
This article provides a comprehensive overview of the cytoskeleton's dynamic role as a central regulator of cellular behavior, bridging fundamental biology with clinical applications.
The Integrated Cytoskeleton: Mechanisms of Actin, Microtubule, and Intermediate Filament Organization in Cell Function and Disease
This article provides a comprehensive analysis of the structure, dynamics, and functional interplay between the three major cytoskeletal systems: actin filaments, microtubules, and intermediate filaments.