Research Articles
Cytoskeletal Remodeling in E-cadherin Mutant Cells: From Architecture to Invasion
This article synthesizes current research on how E-cadherin dysfunction, a hallmark of epithelial cancers and hereditary diffuse gastric cancer (HDGC), triggers profound reorganization of the cytoskeleton.
Beyond Randomness: Uncovering Actin-Microtubule Network Principles with Null Models
This article provides a comprehensive framework for understanding the emergent properties and organizational principles of the composite actin-microtubule cytoskeleton.
Cytoskeletal Blueprint of Invasion: Decoding Architectural Cues in Cancer Cells for Diagnostic and Therapeutic Advancements
This article provides a comprehensive analysis of the distinct cytoskeletal architectures that differentiate invasive from non-invasive cancer cells, tailored for researchers and drug development professionals.
A Computational Workflow for Cytoskeletal Gene Biomarker Identification: From Discovery to Clinical Translation
This article provides a comprehensive guide to the computational identification of cytoskeletal gene biomarkers, a promising frontier for diagnosing and treating age-related and chronic diseases.
Microtubule Lattice Dynamics: From Structural Heterogeneity to Clinical Translation
This article synthesizes recent breakthroughs in understanding microtubule lattice dynamics, moving beyond the traditional view of a static microtubule shaft.
Advanced Methods for Cytoskeletal Network Robustness Analysis: From Computational Tools to Biomedical Applications
This comprehensive review explores cutting-edge computational methods for analyzing cytoskeletal network robustness, a critical determinant of cellular function in health and disease.
Improving Cytoskeletal Reconstitution Assay Reproducibility: From Foundational Principles to Robust Validation
This article provides a comprehensive framework for enhancing the reproducibility of in vitro cytoskeletal reconstitution assays, essential tools for biophysical research and drug development.
Advanced Strategies for Cytoskeletal Drug Target Compound Screening: From Foundational Concepts to Clinical Translation
This article provides a comprehensive overview of modern compound screening strategies targeting the cytoskeleton for drug discovery.
Quantifying Actin Cytoskeleton Disruption: Advanced Assays for Cancer Research and Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on quantifying actin cytoskeleton disruption.
Optimizing Actin-Microtubule Co-Entangled Networks: A Guide to Tunable Mechanics and Biomedical Applications
This article provides a comprehensive resource for researchers and drug development professionals on the engineering and optimization of composite cytoskeletal networks.